What is ppmi

Previously obtained MRI scan with evidence of clinically significant neurological disorder in the opinion of the Investigator Received any of the follow drugs: dopamine receptor blockers neuroleptics , metoclopramide and reserpine within 6 months of Screening visit.

Patients must have a least two of the following: resting tremor, bradykinesia, rigidity must have either resting tremor or bradykinesia ; OR either asymmetric resting tremor or asymmetric bradykinesia. Confirmation of causative LRRK2 or GBA willingness to undergo genetic testing as part of genetic screening and be informed of genetic testing results, or documentation of prior genetic testing results.

Parkinson disease diagnosis at Screening Visit. Confirmation of causative SNCA or rare genetic mutation such as Parkin or Pink 1 willingness to undergo genetic testing as part of genetic screening and be informed of genetic testing results, or documentation of prior genetic testing results.

Exclusion Criteria: PD-SNCA or rate genetic mutation such as Parkin or Pink 1 Received any of the following drugs: dopamine receptor blockers neuroleptics , metoclopramide and reserpine within 6 months of Screening visit. Male or female age 60 years or older except age 30 years or older for SNCA, or rate genetic mutations such as Parkin or Pink1 participants.

Exclusion Criteria : Prodromal Clinical diagnosis of PD, other parkinsonism, or dementia Received any of the following drugs: dopamine receptor blockers neuroleptics , metoclopramide and reserpine within 6 months of Screening visit. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Parkinson Disease. Study Type :.

Estimated Enrollment :. Actual Study Start Date :. Estimated Primary Completion Date :. Estimated Study Completion Date :. Clinical Observation Up to participants will be followed clinically once identified, over the course of years. Principal Investigator: Amy Amara. Principal Investigator: Charles Adler. Principal Investigator: David Shprecher. Principal Investigator: Mark Lew. Principal Investigator: Nikolaus McFarland.

Principal Investigator: Marie H. Saint-Hilaire, MD. Principal Investigator: Kelvin Chou. Sub-Investigator: Un Kang.

Principal Investigator: Giulietta Riboldi. Principal Investigator: Hubert H. Any request by scientists to see or use your secured information must be approved by the study team.

The scientists must sign forms that say they will protect the privacy of the information. They must also respect the laws of scientific research. This does not guarantee there will be no loss of privacy. But we will do everything we can to prevent that. If you have genetic testing as part of PPMI screening, the study will share some results. A genetic counselor will discuss what the results mean for you and your family. PPMI is not set up to return other study results.

We will share updates and results from the study overall. We will report back on new findings and impact of your contribution. The information in this study will have no impact on your job or health insurance.

No one will be told you have participated. Your personal study information will not be shared publicly. There is no cost to you to join this study. All tests are paid for by the research team.

Your health insurance will not be charged. The online part of PPMI captures your data securely, over time, using the internet. The study is expected to continue for several years. The longer you continue to contribute data, the more value you may be able to add. Depending on the information you provide, PPMI may invite you to contribute more to the study.

We may ask you to complete tests through the mail. PPMI may invite you to a medical site for additional testing. If you join PPMI at a medical site, we ask you to participate for at least five years. Many people have been in PPMI for more than a decade. Email info ppmi. We have put together resources to spread the word about PPMI.

Visit michaeljfox. We are always looking to feature PPMI participants in our communications. PPMI makes its data available to qualified researchers. Scientists also may apply for samples for biomarker validation projects. Learn more on the PPMI researcher-facing website. More than 40 private, public and non-profit partners support PPMI. Thank you for your interest in joining us.

Home Page. Search for topics, articles, videos, research, etc Hit enter to search or ESC to close. Are you looking for:. Get Started. About PPMI. Join the study that could change everything. PPMI News. See more. The greatest contributors to PPMI are its volunteers. About PPMI. Fox Foundation. Study Design. Data Dashboard.