The Okazaki group discovered, moreover, that such short fragments accumulated upon impairment of the function of DNA ligase, the enzyme that links together fragments of DNA. By contrast, in the presence of DNA ligase, long strands of DNA were generated from short fragments that were linked together by the ligase [2].
The results obtained by the Okazaki group led to proposal of the model of discontinuous growth of replicating strands of DNA, wherein DNA replication on the lagging strand occurs via formation of short DNA fragments that are subsequently linked together.
The concept of discontinuous growth of replicating DNA gradually gained acceptance but the primers necessary for initiation of the replication process on the lagging strand remained to be identified. Reiji Okazaki passed away prematurely in August , but his wife Tsuneko and their colleagues continued to study the problem and identified the RNA primer responsible for replication [4].
This was the final piece of the puzzle, providing evidence for the model proposed by Tsuneko and Reiji Okazaki. Dictionary Articles Tutorials Biology Forum. Growth and Development of a Human Baby Upon fertilization, a zygote forms and develops into an embryo. The Evolution of Cell Organelles The nucleus containing the genetic material, DNA, and the mitochondria, well-identified as the "powerhouse of the cell",..
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